Mechanically Strong Proteinaceous Fibers:Engineered Fabrication by Microfluidics

• 作者: Jing Sun Jingsi Chen Kai Liu Hongbo Zeng
• 来源期刊: 工程（英文）
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: Green Chemical Engineering:Soft Matter—Review
• 页码范围: 615-623
• 页数: 9页
• 语种: 英文

摘要

Lightweight and mechanically strong natural silk fibers have been extensively investigated over the past decades.Inspired by this research,many artificial spinning techniques(wet spinning,dry spinning,elec-trospinning,etc.)have been developed to fabricate robust protein fibers.As the traditional spinning methods provide poor control over the as-spun fibers,microfluidics has been integrated with these tech-niques to allow the fabrication of biological fibers in a well-designed manner,with simplicity and cost efficiency.The mechanical behavior of the developed fibers can be precisely modulated by controlling the type iop and size of microfluidic channel,flow rate,and shear force.This technique has been success-fully used to manufacture a broad range of protein fibers,and can accelerate the production and applica-tion of protein fibers in various fields.This review outlines recent progress in the design and fabrication of protein-based fibers based on microfluidics.We first briefly discuss the natural spider silk-spinning pro-cess and the microfluidics spinning process.Next,the fabrication and mechanical properties of regener-ated protein fibers via microfluidics are discussed,followed by a discussion of recombinant protein fibers.Other sourced protein fibers are also reviewed in detail.Finally,a brief outlook on the development of microfluidic technology for producing protein fibers is presented.