Controllable photodynamic performance via an acidic microenvironment based on two-dimensional metal-organic frameworks for photodynamic therapy

• 作者: Lifeng Hang Tao Zhang Hua Wen Lianbao Liang Wuming Li Xiaofen Ma Guihua Jiang
• 来源期刊: 纳米研究（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Research Articles
• 页码范围: 660-666
• 页数: 7页
• 语种: 英文

摘要

Photodynamic therapy (PDT) is a widely-used technology for cancer therapy,but conventional photosensitizers still face some drawbacks,such as hydrophobicity,inadequate pharmacokinetics,low cell/tissue specificity,and uncontrollable photodynamic performance during the therapeutic process.Herein,we present a controllable photodynamic performance based on two-dimensioral metal-organic frameworks (2D Zn-TCPP MOF) that displayed a week PDT effect under a neutral environment upon exposure to a 660 nm laser due to the degeneracy of Q bands of TCPP.However,the 2D Zn-TCPP MOF siowed a significantly enhanced PDT effect in an acidic environment under irradiation with a 660 nm laser due to the released TCPP from decomposed MOF structure.From thein vitro outconee,the 2D Zn-TCPP MOF showed controllable photocdynamic perfomnance from neutral to acidic environments.Due to the acldic tumor microenvironment,the 2D Zn-TCPP MOF presented the strongest antitumor effect in vivo under Irradiation with a 660 nm laser.This work offers a promising strategy to develop a next-generation photosensitizer.