On-demand degradable magnetic resonance imaging nanoprobes

• 作者: Wenbo Sun Zonghua Wang Jianhua Liu Chunhuan Jiang Weihua Chen Bin Yu Wei Wang Lehui Lu
• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: ARTICLES
• 页码范围: 676-684
• 页数: 9页
• 语种: 英文

摘要

Theranostic nanoprobes can potentially integrate imaging and therapeutic capabilities into a single platform,offering a new personalized cancer diagnostic tool.However,there is a growing concern that their clinical application is not safe,particularly due to metal-containing elements,such as the gadolinium used in magnetic resonance imaging (MRI).We demonstrate for the first time that the photothermal melting of the DNA duplex helix was a reliable and versatile strategy that enables the on-demand degradation of the gadolinium-containing MRI reporter gene from polydopamine (PDA)-based theranostic nanoprobes.The combination of chemotherapy (doxorubicin) and photothermal therapy,which leads to the enhanced anti-tumor effect.In vivo MRI tracking reveals that renal filtration was able to rapidly clear the free gadolinium-containing MRI reporter from the mice body.This results in a decrease in the long-term toxic effect of theranostic MRI nanoprobes.Our findings may pave the way to address toxicity issues of the theranostic nanoprobes.