Catalytic Benzylation Reactions:From C-H Bond Activation to C-N Bond Activation

• 作者: Tianxiao Jiang Hongchi Liu Haocheng Zhang Hanmin Huang
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: Chemistry Authors Up Close
• 页码范围: 1070-1078
• 页数: 9页
• 语种: 英文
• DOI: 10.1002/cjoc.202000567

摘要

Transition-metal mediated activation of inert chemical bonds is an ongoing topic in homogeneous catalysis.In view of the abundance and accessibility of alkylarenes and benzylamines,the use of them as benzyl source in catalytic benzylation reac-tions via benzylic C-H and C-N bond activation is highly desirable.Indeed,compared with the traditional approaches with benzyl halide as the substrates,benzylation reactions via C-H and C-N bond cleavage provide more efficient,at-om-economic strategies to access myriads of synthetically important molecules.In this account,our group's efforts on catalytic benzylation reactions via directed C-H activation,nondirected C-H activation and C-N bond activation are summarized.