Getting Lost:Place Cells and Grid Cells in Rodent Models of Alzheimer's Disease

• 作者: Xiaoyang Long Yuan Tao Xi-Chan Chen Bin Deng Jing Cai Sheng-Jia Zhang
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: Research Highlights
• 页码范围: 894-897
• 页数: 4页
• 语种: 英文

摘要

Alzheimer's disease (AD) is a progressive neurodegener-ative disorder and affects 60-80％ of all dementia cases in the elderly population worldwide.Getting lost is one of the earliest cognitive symptoms to emerge in AD patients.Despite decades-long efforts to identify the molecular mechanisms underlying the pathogenesis of β-amyloid(Aβ) plaques and tau neurofibrillary tangles,no effective therapeutic interventions have been developed for AD so far [1].The early onset of amnestic deterioration occurs first in the entorhinal cortex and spreads later to the hippocampus,making the hippocampal-entorhinal loop the most vulnerable region.Thus,the hippocampal-entorhinal network has been a primary focus of AD study.