The effects of ischemic stroke with hyperlipidemia on erectile function in rats based on vascular endothelial function

• 作者: Ji-Sheng Wang Hai-Song Li Heng-Heng Dai Sheng Deng Bing-Hao Bao Jun-Long Feng Bin Wang
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2021,（10）
• 所属期刊栏目: Original article
• 页码范围: 30-34
• 页数: 5页
• 语种: 英文

摘要

Objective: To evaluate the effect of ischemic stroke (is) combined with hyperlipidemia (HLP) on erectile function in rats and its mechanism. Methods: Thirty male SD rats were randomly divided into normal group and HLP group. The model of is combined with HLP was established by feeding high-fat diet. The stroke model group and sham operation group were established by operation method. The contents of testosterone (T), D-Dimer (D-D) and cyclic guanosine (cGMP) were detected by ELISA. Western blot and real-time PCR were used to detect the expression of VEGF protein and mRNA, and hematoxylin and eosin (He) staining of penile tissue were observed to evaluate its erectile function. Results: Compared with group C, the levels of cGMP and T in group M decreased, while VEGF and D-D increased. He staining showed that the tissue structure of corpus cavernosum in model group was obviously damaged. Conclusion: The model of ischemic stroke combined with hyperlipidemia has certain effect on erectile function of rats, and the mechanism may be related to the expression of cGMP, VEGF related protein and mRNA.