When aggregation-induced emission meets protein aggregates

• 作者: Sicheng Tang Songtao Ye Xin Zhang
• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: Special Topic:Aggregation-Induced Emission
• 页码范围: 7-9
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/nsr/nwab013

摘要

Protein misfolding and aggregation have been associated with a number of hu-man diseases.As a multistep process(Fig.1a),protein unfolding yields mis-folded intermediates as either monomers or oligomers,which evolve into insolu-ble aggregates as amorphous aggregates or amyloid-β fibrils.Detection of pro-tein aggregates is of great interest as it could generate unprecedented insights into biogenesis,regulation and pathology of protein aggregation.Previous efforts using fluorescence detection have gener-ated various fluorophores with different fluorescence turn-on mechanisms and a wide spectrum coverage.However,the π-rich conjugated system of these tra-ditional fluorophores often suffers from aggregation caused quenching (ACQ).