A Potential Novel Indication for Preventing Thromboembolism in Patients with Atrial Arrhythmias:Remodeling of the Left Atrium

• 作者: Chen LIU Shuang LIU Hui LI Yu-long GUO
• 来源期刊: 当代医学科学（英文）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 1187-1191
• 页数: 5页
• 语种: 英文
• DOI: 10.1007/s11596-021-2449-4

摘要

Objective:Thrombosis in patients with atrial arrhythmias might be associated with remodeling of the left atrium(LA).We aimed to describe this relationship and identify a novel factor,in addition to the CHA2DS2-VASc score,to guide therapeutic strategies for preventing thromboembolism in the hope of improving the prognosis for such patients.Methods:Patients diagnosed with atrial arrhythmias and who met our inclusion criteria were enrolled in this study.Various clinical parameters were recorded;diameters reflecting remodeling of the LA were measured and thrombosis was diagnosed by enhanced CT.Results:Totally,192 patients were enrolled in the study.The overall prevalence of left atrial thrombosis was 8.3％.Patients with persistent atrial fibrillation exhibited the highest anteroposterior diameter of the LA(45.1±7.2 mm)and prevalence of thrombosis(15.6％).An anteroposterior LA diameter of≥50 mm was a strong independent impact risk factor for thrombosis(OR=10.1,95％CI:2.8-36.9,P＜0.00l).The prevalence of LA thrombosis in patients with and without anteroposterior LA diameter of≥50 mm was 25.8％and 5.0％,respectively.Conclusion:Marked remodeling of the LA characterized by an anteroposterior LA diameter of≥50 mm is a strong independent risk factor of thrombosis,and should be considered for the prevention of thromboembolism through various strategies.