Clerodenoids A—F:C-ring Aromatized and/or Rearranged Abietane Diterpenoids from Clerodendrum chinense var.simplex

• 作者: Jingjing Qi Yan Zhang Qunfang Liu Hongchun Liu Yaoyue Fan Jianmin Yue
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Concise Reports
• 页码范围: 1891-1897
• 页数: 7页
• 语种: 英文
• DOI: 10.1002/cjoc.202100117

摘要

Main observation and conclusion As part of our continuing efforts toward the discovery of the biologically active diterpenoids from medicinal plants,six new C-ring aromatized abietane diterpenoids,clerodenoids A—F (1-6),were isolated from Clerodendrum chinense.These C-ring aromatized compounds mainly belonged to the rearranged abietane skeletons of 17(15→16)-abeo-abietane (2-4) and 17(15→16),18(4→3)-diabeo-abietane (5 and 6).Their structures were elucidated by extensive spectroscopic data,X-ray crystallography,and ECD calculation.Compounds 5 and 6 displayed strong antiprotiferative activities against A549 and HL-60 cell lines.