Research progress of soluble CD83 in organ transplantation

• 作者: Liang-Xing Xiong Liang-Hui Gao
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Review and lectures
• 页码范围: 57-60
• 页数: 4页
• 语种: 英文

摘要

Organ transplantation is considered to be an effective method for the treatment of end-stage organ failure, early malignant tumors and tissue damage. In order to reduce the rejection of the transplanted organ by the host, immunosuppressive drugs should be used for a long time, but the suppression of the host immune system by immunosuppressive drugs can cause serious side effects. Therefore, how to induce the recipient's immune system to have no response to the transplanted organ after transplantation, while still showing a normal immune response to the alien antigen. Induction of immune tolerance to donor organs has long been a focus of research by transplant scientists. Soluble CD83 (sCD83) is a glycoprotein with specific immunosuppressive effects. In recent years, there have been more and more reports on the immune tolerance induced by sCD83 in animal experiments, which has shown a broad prospect in the treatment of host immune rejection after organ transplantation and provided an experimental basis for its clinical transformation.