Effects of electroacupuncture of acupoints of the neiguan and ximen on ischemic myocardium energy metabolism with acute myocardial ischemia rats

• 作者: Jing Zhou Li Ding Kun Deng Yan Zhang Guang-Bing Li Tao Zhu Qiao Zhou Kun Wang Chen Zhang
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2021,（15）
• 所属期刊栏目: Original article
• 页码范围: 6-10
• 页数: 5页
• 语种: 英文

摘要

Objective: To observe the effect of Electroacupuncture of Acupoints of the Neiguan(PC6) and Ximen(PC4) on its myocardial energy metabolism with acute myocardial ischemia rats caused by coronary artery ligation. Methods: Forty standard Spargue-Dawely(SD) rats were divided into four groups randomly, namely, group of Neiguan, group of Ximen, model group, sham group. The group of rats of myocardial ischemia were induced by coronary ligation, and the model rat of acute myocardial ischemia was prepared. The sham group had no ligation of the needle. After anesthesia was awakened, acupuncture was applied bilateral at Neiguan and Ximen of the group of Neiguan and Ximen, once a day at a fixed time for 14 days. The rats of model group and the sham group were not given acupunctured, but use the samely methods of Neiguan and Ximen groups to grap the rats at the same time everyday .After 14 days the experiment was over,observed the pathological changes of myocardial tissue by HE staining, detected the levels of free fatty acid (FFA), adenosine triphosphate (ATP) content, and the activities of Na+-K+-ATPase according to the reagents′demand. Results: Pathological results showed that acupuncuted at Neiguan and Ximen could improve the ischemic cardiomyocyte injury.Compared with the sham group, the levels of FFA in model group were increased (p<0.01), the levels of ATP,the activities of Na+-K+-ATPase were all decreased (p<0.01); Compared with the model group, the levels of FFA were decreased (p<0.05,p<0.01), the levels of ATP,the activities of Na+-K+-ATPase were improved. Conclusion: Acupuncturing at the Pericardium Meridian can alleviate the cell injury by myocardial ischemia,and also can improve the myocardial energetic metabolism in acute myocardial ischemia.