Clinical observation of electroacupuncture "Tongmin Point" combined with heat-sensitive moxibustion on knee osteoarthritis and its influence on blood lipid level and ADAMTS-4

• 作者: Zhen Mao Run Jiang Yong-Hong Liu Jun Duan Jian-Chao Fan Hong-Xing Zhang
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2021,（16）
• 所属期刊栏目: Original article
• 页码范围: 12-17
• 页数: 6页
• 语种: 英文

摘要

Objective: To observe the clinical effect of electroacupuncture "Tongmin point" combined with heat-sensitive moxibustion on knee osteoarthritis and its effect on blood lipid level, polyprotein polysaccharide enzyme-4(a disintegrin and metalloprotease with thrombospondin motifs, ADAMTS-4, matrix metalloproteinase-3(matrix metalloproteinase-3,); and MMPs-3) Impact. Methods: 80 patients were randomly divided into two groups, 40 cases per group, Treatment and control groups, The treatment group was given electroacupuncture combined with heat-sensitive moxibustion, Six times a week, Continuous treatment for 4 weeks; The control group was given intraarticular sodium hyaluronate, Once a week, continuous treatment for 4 weeks. Results: During the treatment period, Visual analogue scale visual analogue scale, VAS) show a downward trend, Intra-group comparisons, Differences were statistically significant (P<0.05); After 2 weeks of treatment ,4 weeks of treatment and 2 weeks of follow-up, All the scores in the treatment group were lower than those in the control group (P<0.05). After treatment in two groups (The Western Ontario and Mc Master Universities Osteoarthritis Index,) of osteoarthritis index, University of Western Ontario WOMAC) The scores of each item decreased significantly, treatment group was better than the control group (P<0.05). After four weeks of treatment, (Total cholesterol,) Total cholesterol TC, triglycerides (Triglyceride,); and TG, LDL (Low density lipoprotein,); and LDL-C) A decrease in content, High density lipoprotein High density lipoprotein, HDL-C) Increased content, and the improvement was better than that of the control group (P<0.05). After treatment, the ADAMTS-4, MMPs-3 content decreased, Intergroup comparisons, Differences were statistically significant (P<0.05); The effective rate in the treatment group was 87.5％, The control rate was 60％, treatment group was more effective (P<0.05). Conclusions: Electroacupuncture "Tongmin point" combined with heat-sensitive moxibustion can obviously improve the symptoms of knee osteoarthritis patients, Regulate blood lipids, High security, It is worth popularizing in clinic.