Cu/Pd-catalyzed borocarbonylative trifunctionalization of alkynes and allenes:synthesis of β-geminal-diboryl ketones

• 作者: Yang Yuan Fu-Peng Wu Anke Spannenberg Xiao-Feng Wu
• 来源期刊: 中国科学：化学（英文版）
• 年，卷（期）: 2021,（12）
• 所属期刊栏目: ARTICLES
• 页码范围: 2142-2153
• 页数: 12页
• 语种: 英文

摘要

Functionalized bisboryl compounds have recently emerged as a new class of synthetically useful building blocks in organic synthesis.Herein,we report an efficient strategy to synthesize β-geminal-diboryl ketones enabled by a Cu/Pd-catalyzed bor-ocarbonylative trifunctionalization of readily available alkynes and allenes.This reaction promises to be a useful method for the synthesis of functionalized β-geminal-diboryl ketones with broad functional group tolerance.Mechanistic studies suggest that the reaction proceeds through borocarbonylation/hydroboration cascade of both alkynes and allenes.