Catellani Reaction:An Enabling Technology for Vicinal Functionalization of Aryl Halides by Palladium(o)/Norbornene Cooperative Catalysis

• 作者: Sichan Dong Xinjun Luan
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: Cornerstones in Chemistry
• 页码范围: 1690-1705
• 页数: 16页
• 语种: 英文
• DOI: 10.1002/cjoc.202000600

摘要

The Catellani reaction,originally discovered by Catellani in 1997,and further developed by Catellani,Lautens and others,has emerged as a powerful strategy for the synthesis of polysubstituted arenes,which would be difficult to access via traditional meth-ods.In this process,both ortho-and ipso-positions of aryl halides could be functionalized simultaneously with different electrophiles and terminating agents under the cooperative catalysis of palladium and norbornene(NBE).This review focuses on the significant progress of such transformations,and the section of typical Catellani reactions is divided into five parts according to the functionali-zation mode of ortho-C-H bond:alkylation,arylation,amination,acylation or thiolation.