Amyloid hypothesis through the lens of Aβ supersaturation

• 作者: Zhefeng Guo
• 来源期刊: 中国神经再生研究（英文版）
• 年，卷（期）: 2021,（8）
• 所属期刊栏目: Perspectives
• 页码范围: 1562-1563
• 页数: 2页
• 语种: 英文

摘要

Deposition of aggregated amyloid-β (Aβ) protein in the form of amyloid plaques is a pathological hallmark of Alzheimer's disease. According to the amyloid hypothesis, Aβ aggregation initiates a pathogenic cascade, eventually leading to dementia. Being the prevailing theory for Alzheimer's disease, amyloid hypothesis has been used to guide basic research and therapeutic interventions. Supersaturation is a phenomenon that occurs when the concentration of a solute in the solution exceeds its thermodynamic solubility.