Egg white as a natural and safe biomaterial for enhanced cancer therapy

• 作者: Jun Huang Xinru You Peikun Xin Zhipeng Gu Chun Chen Jun Wu
• 来源期刊: 中国化学快报（英文版）
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: Communications
• 页码范围: 1737-1742
• 页数: 6页
• 语种: 英文

摘要

The last few decades have witnessed the emergence of a very large variety of engineered nanomaterials.However,it is far from to meet the growing clinical demand.Actually,nature itself is an excellent nanotechnologist,and provides us with a range of wonderful materials,from inorganic particles found in non-life bodies to biofilms,like platelets,erythrocyte membranes,produced by many bacteria or cells.These nanomaterials are entirely natural,and not surprisingly,there is a growing interest in the development of natural nanoproducts.Native components-inspired biomaterials have gained consider-able attention owing to their safety and functions.In this study,egg white was developed as drug carrier to load PTX by a green and simple one-pot method,and systematic characterization was completed.The results indicated that PTX@EW NPs possess excellent biocompatibility,enhanced tumor targeting capability,effectively reducing the toxic side effects of PTX.The obviously enhanced antitumor effect further confirmed EW was a highly prospective biomaterial in the nano-carrier industry.