Regulating autophagy: a novel role for SETX (Senataxin)

• 作者: Patricia Richard Emanuel Rosonina
• 来源期刊: 中国神经再生研究（英文版）
• 年，卷（期）: 2021,（10）
• 所属期刊栏目: Perspectives
• 页码范围: 2008-2009
• 页数: 2页
• 语种: 英文

摘要

Mutations in the gene encoding SETX, also known as Senataxin, are mainly linked to two distinct neurodegenerative diseases, a cerebellar ataxia known as oculomotor apraxia type 2 (AOA2) and a form of juvenile amyotrophic lateral sclerosis, ALS4 (Chen et al., 2004;Moreira et al., 2004). SETX is an RNA/DNA helicase that functions in multiple events related to RNA metabolism and DNA maintenance, including transcriptional termination at certain genes and the DNA damage response at replication stress foci.