The dual role of necrostatin-1 in Parkinson's disease models

• 作者: Eva Alegre-Cortés Guadalupe Martínez-Chacón José M.Fuentes Sokhna M.S.Yakhine-Diop
• 来源期刊: 中国神经再生研究（英文版）
• 年，卷（期）: 2021,（10）
• 所属期刊栏目: Perspectives
• 页码范围: 2019-2020
• 页数: 2页
• 语种: 英文

摘要

Neuronal cell death is the main hallmark of Parkinson's disease (PD). It is an irreversible process promoted by neurotoxins and/or genetic mutations. Different types of cell death have been associated with PD. The mechanisms by which neurons decide to specific type of cell death remain elusive. However, it is well known that cell death can be either programmed or not. Apoptosis is a programmed cell death that involves the release of cytochrome C from damaged mitochondria to cytosol and the activation of caspases leading to nuclear condensation. Necrosis is a caspase-independent cell death characterized by a gain in cell volume, rupture of plasma membrane and leak of cell contents, inflammation, and affects neighbouring cells. It was classified as a non-programmed cell death, but there are types of necrotic death triggered by a protein activation cascade, including necroptosis.