Baseline left ventricular ejection fraction associated with symptom improvements in both children and adolescents with postural tachycardia syndrome under metoprolol therapy

• 作者: Wang Yuan-Yuan Han Zhen-Hui Wang Yu-Li Liao Ying Zhang Chun-Yu Liu Ping Tang Chao-Shu Du Jun-Bao Jin Hong-Fang Huang Ya-Qian
• 来源期刊: 中华医学杂志英文版
• 关键词: Children Left ventricular ejection fraction Left ventricular fractional shortening Metoprolol Postural tachycardia syndrome
• 年，卷（期）: 2021,（16）
• 所属期刊栏目: Original Article
• 页码范围: 1977-1982
• 页数: 6页
• 语种: 中文
• DOI: 10.1097/CM9.0000000000001698

摘要

Background::Postural tachycardia syndrome (POTS) is a common childhood disease that seriously affects the patient’s physical and mental health. This study aimed to investigate whether pre-treatment baseline left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) values were associated with symptom improvement after metoprolol therapy for children and adolescents with POTS.Methods::This retrospective study evaluated 51 children and adolescents with POTS who received metoprolol therapy at the Peking University First Hospital between November 2010 and July 2019. All patients had completed a standing test or basic head-up tilt test and cardiac echocardiography before treatment. Treatment response was evaluated 3 months after starting metoprolol therapy. The pre-treatment baseline LVEF and LVFS values were evaluated for correlations with decreases in the symptom score after treatment (ΔSS). Multivariable analysis was performed using factors with a P value of <0.100 in the univariate analyses and the demographic characteristics. Results::A comparison of responders and non-responders revealed no significant differences in demographic, hemodynamic characteristics, and urine specific gravity (all P > 0.050). However, responders had significantly higher baseline LVEF (71.09% ± 4.44% vs. 67.17% ± 4.88%, t = -2.789, P = 0.008) and LVFS values (40.00 [38.00, 42.00]% vs. 36.79% ± 4.11%, Z = -2.542, P = 0.010) than the non-responders. The baseline LVEF and LVFS were positively correlated with ΔSS ( r = 0.378, P = 0.006; r = 0.363, P = 0.009), respectively. Logistic regression analysis revealed that LVEF was independently associated with the response to metoprolol therapy in children and adolescents with POTS (odds ratio: 1.201, 95% confidence interval: 1.039-1.387, P = 0.013). Conclusions::Pre-treatment baseline LVEF was associated with symptom improvement after metoprolol treatment for children and adolescents with POTS.