How long should a kiss last between a kinase and its substrate? FA

• 作者: Chen Zhu Liwen Fu Yan Xiong Pengcheng Wang
• 来源期刊: 植物学报（英文版）
• 年，卷（期）: 2022,（4）
• 所属期刊栏目: Commentary
• 页码范围: 789-791
• 页数: 3页
• 语种: 英文

摘要

The molecular mechanisms underlying the trade-off be-tween plant growth and responses to the ever-changing environment are poorly understood. We previously revealed a phosphorylation-based regulatory loop between the plant stress hormone abscisic acid (ABA) and the central growth regulator Target of Rapamycin (TOR) (Wang et al., 2018). Under normal conditions, TOR kinase phosphorylates ABA receptors (PYR1/PYL/RCARs) to abolish their ABA binding ability, thereby preventing stress signaling activation and promoting plant growth. Under stress conditions, ABA binds to PYR1/PYLs/RCARs and releases the protein kinase SnRK2s from PP2C-mediated inhibition. The activated SnRK2s then phosphorylate Raptor1B, a regulatory compo-nent in the TOR complex (Wang et al., 2018), inhibiting TOR signaling and plant growth.