The role of MT1-MMP in the progression and metastasis of osteosarcoma

• 作者: Hannah L.M.Spencer Steven D.Shnyder Paul M.Loadman Robert A.Falconer
• 来源期刊: 癌症转移与治疗（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Review
• 页码范围: 1-15
• 页数: 15页
• 语种: 英文
• DOI: 10.20517/2394-4722.2021.174

摘要

The dysregulation of Membrane - type 1 matrix metalloproteinase (MT1-MMP) has been extensively studied in numerous cancer types, and plays key roles in angiogenesis, cancer progression, and metastasis. MT1-MMP is a predictor of poor prognosis in osteosarcoma (OS), yet the molecular mechanisms of disease progression are unclear. This review provides a summary of the literature relating to the gene and protein expression of MT1-MMP (MMP-14) in OS clinical samples, evaluates the expression in cell lines and experimental models, and analyses its potential role in the progression and metastasis of OS. In addition, the therapeutic potential of MT1-MMP as a drug target has been assessed. Due to the biological complexity of MMPs, inhibition has proven to be challenging. However, exploiting the expression and proteolytic capacity of MT1-MMP could open new avenues in the search for novel, safer and selective drugs for use in OS.