A systematic review and meta-analysis for platelet-rich plasma in treatment of knee osteoarthritis

• 作者: Rong Xie Shang-Quan Wang Ling-Hui Li Xu Wei Jie Yu Jia-Wen Zhan Rui Xie Xiao-Juan Chang Li-Guo Zhu
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2022,（4）
• 所属期刊栏目: Original article
• 页码范围: 29-36
• 页数: 8页
• 语种: 英文

摘要

Objective: To systematically evaluate the efficacy and safety of platelet-rich plasma in patients with knee osteoarthritis. Methods: The Pubmed, Cochrane Library, Embase,and Medline were investigated from 2005 through May 2020.All randomized double-blind controlled trials were included the effect of PRP injections for KOA. Literature screening and data extraction were carried out independently by two researchers, and the quality of the included randomized controlled trials was evaluated one by one according to the Cochrane collaboration standards. Meta-statistical analysis was performed for the studies that met the inclusion standards using RevMan5.3. Results: In this study,(1)Seven studies met the eligibility criteria, including 250 patients in the experiment (PRP)group and 230patients in the control(no PRP)group.(2)Meta-analysis results showed that the WOMAC Scores was differed significantly between the PRP and no PRP groups at the 6 months follow-up(MD=9.63,95％CI:3.29 to 15.96,P=0.003),and 12 months follow-up(MD=3.85,95％CI:2.66 to 5.04,P<0.00001)(P<0.05).In a comparison of KOOS function scores at the 6 months follow-up, PRP improved knee function scores more than no PRP(MD=8.63,95％CI:0.85 to 16.42,P=0.03) (P<0.05).PRP injections reduced pain more effectively than no PRP injections in patients with KOA at 3,6 months of follow-up, and the VAS pain score showed a significant difference(SMD=0.88,95％CI:0.13 to 1.62,P=0.02) (SMD=0.85,95％CI:0.11 to 1.59,P=0.002)(P<0.05). However, Adverse Events (AEs) were all not significantly different(RR=0.96,95％CI:0.65 to 1.40,P=0.82)(P>0.05).(3)Results showed that PRP has significant advantages in pain relief and functional improvement. Conclusions: In improving knee function and relieving pain, PRP showed superiority to other non-surgical treatments in long-term follow-up from well-designed double-blind trials. Due to the limited quality and data, more high-quality multi-center studies are required.