Sex differences in SARS-CoV-2 infections, anti-viral immunity and vaccine responses

• 作者: Abhishek Mohanty Aanchal Sawhney Shefali Gupta Vishal Rao Periyasamy Govindaraj Sambit Mohanty Vandana Jain
• 来源期刊: 亚太热带医药杂志（英文版）
• 年，卷（期）: 2022,（3）
• 所属期刊栏目: Review Article
• 页码范围: 97-105
• 页数: 9页
• 语种: 英文
• DOI: 10.4103/1995-7645.340567

摘要

The COVID-19 pandemic has revealed sex-based differences in anti-viral responses, with a higher rate of SARS-CoV-2 infections as well as a higher rate of morbidity and mortality in men than in women. Males and females also show disparate immune responses to COVID-19 infection, which may be important contributors to lower rates of infection, disease severity and deaths in women than in men. Here, the authors review sex differences in SARS-CoV-2 infections, anti-viral immunity and vaccine responses, putting forth the importance of sex, the underappreciated variables in vaccine response and disease infectivity.