Fluorescent traceable nanoparticles by co-self-assembly of carbon dot-drug conjugate and biodegradable hyperbranched polymer for diagnosis and therapy

• 作者: Guoping Li Mingliang Pei Xinming Li Peng Liu
• 来源期刊: 颗粒学报（英文版）
• 年，卷（期）: 2022,（3）
• 页码范围: 79-87
• 页数: 9页
• 语种: 英文

摘要

Carbon dots (CDs) have attracted more interest in tumor theranostics,but they suffer from the rapid renal clearance due to small size and high hydrophilicity.To solve such problems,hydrophobic pH-triggered carbon dot-drug conjugate (CDs-Hy-DOX) with high doxorubicin (DOX) content of 48.23％were designed by covalent conjugation of DOX onto the CDs via acid-labile linkage with hydrazine (Hy) as bridge.Then the fluorescent traceable hybrid prodrug nanoparticles were fabricated via co-self-assembly with the CDs-Hy-DOX as pH-sensitive prodrug and a pH]reduction dual-triggered degradable hyper-branched polymer PEG-PO-Cy as polyethylene glycol (PEG)-based surfactant,as well as gatekeeper for pH/reduction dual-triggered DOX release.The hybrid prodrug nanoparticles with hydrodynamic diame-ter of 220 nm and DOX content of 22.99％ were obtained with the optimized co-self-assembling condition.They could release 68.98％ of DOX in the simulated tumor microenvironment within 3 days in a sustained release mode,with a premature drug leakage of 7.58％.After the acid-triggered DOX release from the CDs-Hy-DOX,which was accelerated by the pH/reduction dual-triggered degradation of the hyperbranched polymer,the strong fluorescence of CDs-Hy was recovered,demonstrating the promising potential in future tumor nanotheranostics.