Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and Variants of Concern

• 作者: Jingwen Ai Haocheng Zhang Qiran Zhang Yi Zhang Ke Lin Zhangfan Fu Jieyu Song Yuanhan Zhao Mingxiang Fan Hongyu Wang Chao Qiu Yang Zhou Wenhong Zhang
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: LETTERS TO THE EDITOR
• 页码范围: 103-106
• 页数: 4页
• 语种: 英文

摘要

Dear Editor, As of October,2021,SARS-CoV-2 has infected more than 230 million people;promoting roll-out vaccinations could help build herd immunity for the pandemic.However,the waning of antibody in magnitude and decreased protective efficacy in multiple types of vaccines have been reported:Along with the circulating variants to some degree escaping from immune response,these led to the argument of further booster vaccination in recipients who have previously received "priming" vaccination.