Transcriptional Regulation of YP3680 by RovA and RcsAB in Yersinia pestis biovar Microtus

• 作者: LIU Lei FANG Nan LIU Wan Bing HE Ying Yu LIU Yan ZHANG Yi Quan
• 来源期刊: 生物医学与环境科学（英文版）
• 年，卷（期）: 2022,（3）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 234-238,前插22
• 页数: 6页
• 语种: 英文
• DOI: 10.3967/bes2022.032

摘要

Type-VI secretion system (T6SS) is a widespread bacteriophage-like complex in bacteria that participates in multiple physiological processes, including metal ion uptake, bacterial competition, and biofilm formation[1]. Yersinia pestis is the causative agent of plague. There are five T6SS gene clusters in Y. pestis CO92, among which only the YPO0499-YPO0516 locus was well investigated[1,2]. The expression of YPO0499-YPO0516 is induced at 26 °C, suggesting that it plays a possible role in the natural cycle of Y. pestis[2]. Deletion of YPO0499-YPO0516 alters the uptake and intracellular growth of Y. pestis in macrophages, which is dependent on the pre-grown temperature[2]. However, it has no effect on the virulence in murine and on the ability of the pathogen to infect fleas[2]. The Hcp-like protein encoded by YPO0502 was shown to be an autoagglutination factor involved in the bacterial interaction[3].