Cytogenetic Characteristics of Childhood Acute Lymphoblastic Leukemia:A Study of 1541 Chinese Patients Newly Diagnosed between 2001 and 2014

• 作者: Meng-meng YIN Rui-chi WU Jing GAO Shao-yan HU Xiao-ming LIU Xiao-fan ZHU Shu-hong SHEN Jing-yan TANG Jing CHEN Qun HU
• 来源期刊: 当代医学科学（英文）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 201-209
• 页数: 9页
• 语种: 英文
• DOI: 10.1007/s11596-021-2477-0

摘要

Objective:Cytogenetic abnormalities have been proven to be the most valuable parameter for risk stratification of childhood acute lymphoblastic leukemia(ALL).However,studies on the prevalence of cytogenetic abnormalities and their correlation to clinical features in Chinese pediatric patients are limited,especially large-scale studies.Methods:We collected the cytogenetics and clinical data of 1541 children newly diagnosed with ALL between 2001 and 2014 in four Chinese hospitals,and retrospectively analyzed their clinical features,prognosis and risk factors associated with pediatric ALL.Results:All of these patients had karyotyping results,and some of them were tested for fusion genes by fluorescence in situ hybridization or reverse-transcription polymerase chain reaction.Overall,930 cases(60.4％)had abnormal cytogenetics in this study,mainly including high hyperdiploidy(HHD,n=276,17.9％),hypodiploidy(n=74,4.8％),t(12;21)/TEL-AML 1(n=260,16.9％),t(1;19)/E2A-PBX1(n=72,4.7％),t(9;22)/BCR-ABL(n=64,4.2％),and t(v;11q23)/MLL rearrangements(n=40,2.6％).The distribution of each cytogenetic abnormality was correlated with gender,age,white blood cell count at diagnosis,and immunophenotype.In addition,multivariate analysis suggested that t(v;11q23)/MLL rearrangements(OR:2.317,95％CI:1.219-3.748,P=0.008)and t(9;22)/BCR-ABL(OR:2.519,95％CI:1.59-3.992,P＜0.001)were independent risk factors for a lower event-free survival(EFS)rate in children with ALL,while HHD(OR:0.638,95％CI:0.455-0.894,P=0.009)and t(12;21)/TEL-AML1(OR:0.486,95％CI:0.333-0.707,P＜0.001)were independent factors of a favorable EFS.Conclusion:The cytogenetic characteristics presented in our study resembled other research groups,emphasizing the important role of cytogenetic and molecular genetic classification in ALL,especially in B-ALL.