3D printing in the textile and fashion industry is a new emerging technology. Applications of 3D printing for designing clothes and other wearable accessories require tribological and biological understanding of 3D printing plastics against the complex human skin to mitigate skin-friction related ailments such as calluses and blisters. This study provides tribological insight in search of an optimal 3D printable material that has minimal friction against the skin. Two low friction 3D printable materials, thermoplastic polyurethane (TPU) and polyamide (TPA) were chosen and tribological testing was carried out against a water responsive skin model. The skin model was synthesized using a gelatine based model made with cotton and crosslinked with glutaraldehyde. Tribological testing of TPU/TPA against the skin model in dry and wet conditions were made. The higher coefficient of friction (COF) was observed in the wet condition compared to the dry condition. To overcome the higher friction, TPA/TPU-sodium polyacrylate composites were prepared by heat pressing that significantly reduced COF of TPU and TPA by ~ 40% and 75%, respectively, in wet conditions.