Gene-Environment Interactions between Environmental Noise and ApoE4 Causes AD-Like Neuropathology in the Hippocampus in Male Rats

• 作者: LI Wen Long LI Yuan Yuan LI Yu Xin FU Yu HE Xian Zhi TAO Fei Yan YOU Ruo Lan ZHANG Ruo Yu ZHONG Ming Qing CHI Hui Min ZHAI Qing Feng
• 来源期刊: 生物医学与环境科学（英文版）
• 年，卷（期）: 2022,（3）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 270-275,前插28-前插29
• 页数: 1页
• 语种: 英文
• DOI: 10.3967/bes2022.038

摘要

Experimental evidence has demonstrated that environmental hazards can induce neurodegeneration such as Alzheimer's disease (AD)[1]. The pathogenesis of AD, characterized by a gradual cognitive decline, overproduction of β-amyloid (Aβ), and hyperphosphorylated tau in specific brain areas, is considered to involve the interaction of several internal (individual) and external environmental factors.