Mono-2-ethylhexyl Phthalate Promotes Migration and Invasion by Regulating the Epithelial-Mesenchymal Transition in SH- SY5Y Cells

• 作者: XU Qi ZHANG Bo LI Xu YE Jia Ming HUO Chuan Yi YIN Jian Li ZHANG Ru Xuan ZHAO Wei Sen QI Wen YE Lin
• 来源期刊: 生物医学与环境科学（英文版）
• 年，卷（期）: 2022,（3）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 276-281
• 页数: 6页
• 语种: 英文
• DOI: 10.3967/bes2022.039

摘要

Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. It accounts for 8％–10％ of all malignant tumors in children[1] and results in a heavy burden to the life and health of children. NB is a complex disease, and its occurrence is related to exposure to environmental risk factors. Children of parents who are occupationally exposed to environmental endocrine disruptors (EEDs) such as paint have a significantly higher risk of NB[2]. Di-2-ethylhcxylphthalate (DEHP) is a widespread EED that can interfere with a variety of neurotransmitters, affect the differentiation, proliferation and migration of neurons, and cause damage to the nervous system, thereby increasing the risk of neurological tumors such as NB in children[3]. DEHP enters the human body, where it is metabolized into mono-2-ethylhexyl phthalate (MEHP). MEHP has been detected in human blood, breast milk, and urine. In a previous study, we found that MEHP promoted the proliferation of SH-SY5Y cells and upregulated matrix metalloproteinase-2 (MMP-2) and MMP-9 to promote the migration of SH-SY5Y cells[3]. However, the mechanism by which MEHP promotes the migration of SH-SY5Y cells remains unclear.