Syntheses,Crystal Structures and DNA-Binding Properties of Zn(Ⅱ)and Mn(Ⅱ)Complexes Based on Imidazole Derivatives and Carboxylic Acid

• 作者: GUAN Hui-Chao SONG Xiao-Tong LIU Gui-Bao YUE Shu-Mei
• 来源期刊: 结构化学
• 年，卷（期）: 2022,（3）
• 页码范围: 260-269
• 页数: 10页
• 语种: 英文
• DOI: 10.14102/j.cnki.0254-5861.2011-3363

摘要

Complexes[Zn(pbm)(5-hip)3](1),[Zn(pbm)(5-nip)3](2),[Mn(pbm)(H3btc)2(H2O)](3)and[Mn(pbm)(5-nip)3](4),where H2HIPA=5-hydroxyisophthalic acid,H2nip=5-nitroisophthalic acid,H3btc=tri-mesic acid and pbm(pyridine benzene chelate material)=2-(2-pyridyl)benzimidazole,were identified via sin-gle-crystal XRD analyses.1,2 and 4 pertain to the monoclinic space group C2/c,while 3 belongs to the triclinic space group P1.The interplay of CT-DNA with those complexes was delineated using ultraviolet,fluorescence,and circular dichroism(CD)spectroscopy and viscosity measurements.Complexes 1,2,3 and 4 interact with CT-DNA in an electrostatic or grooving mode.We wish to offer a theory-wise foundation for developing anti-tumor medi-cines.