STEREOSELECTIVE TOTAL SYNTHESIS OF CHRYSANTHEMOL

• 来源期刊: 亚洲天然物产研究（英文版）
• 学科: 生物学
• 关键词: Chrysanthemol (1) Total synthesis Anti-inflammatory activity
• 年，卷（期）: 2001,（2）
• 页码范围: 103-116
• 页数: 14页
• 分类号: Q94
• 语种: 英文

摘要

Chrysanthemol (1), a trans-eudesmane type sesquiterpene from Chrysanthemum indicum L.,possesses certain anti-inflammatory activity. Its total synthesis was approached from two alternative routes and finally accomplished in ten steps from R-(+)-carvone via α-eudesmol (10) as the key intermediate. The overall yield is 2.4% and the spectral data of the synthetic target compound were identical with that of natural chrysanthemol (1). Seven intermediary compounds were tested for inhibitory effects on the carragenan-induced swelling of mouse paw but demonstrated no obvious activities.