A NEW SESQUITERPENE LACTONE FROM TSOONGIODENDRON ODORUM CHUN

• 来源期刊: 亚洲天然物产研究（英文版）
• 学科: 生物学
• 关键词: Tsoongiodendron odorum Chun Sesquiterpene lactones Cytotoxic activity
• 年，卷（期）: 2001,（4）
• 页码范围: 285-291
• 页数: 7页
• 分类号: Q94
• 语种: 英文

摘要

A new sesquiterpene lactone (1) was obtained from the cytotoxic fraction of 95% ethanol extract of root barks of Tsoongiodendron odorum Chun together with two known sesquiterpene lactones, costunolide (2) and parthenolide (3). The structure of 1 was elucidated as 5α, 6α, 7β, 10β-1 lα,13-dihydro-4(15)-eudesmene-12, 6-olide on the basis of chemical and spectral evidence includ ing X-ray diffraction analysis. Costunolide showed cytotoxic activity against human leukemia (HL-60) cell line. Parthenolide showed promising cytotoxic activities in vitro against HCT-8, Bel 7402, SKOV3, KB, HELA and EJ cell lines. Also, the cytotoxic ethyl acetate fraction of ethanol extract of the root barks from which three chemical components were isolated showed promising cytotoxic activities in vitro against KB, BGC-823, Bel-7402, HCT-8, HL-60 cell lines.