A NEW BICOUMARIN FROM STELLERA CHAMAEJASME L.

• 来源期刊: 亚洲天然物产研究（英文版）
• 学科: 生物学
• 关键词: Stellera chamaejasme L. Thymelaeaceae Bicoumarins
• 年，卷（期）: 2001,（4）
• 页码范围: 335-340
• 页数: 6页
• 分类号: Q94
• 语种: 英文

摘要

Thirteen compounds were isolated from roots of Stellera chamaejasme L. (Thymelaeaceae).They are β-sitosterol (2), simplexin (3), pimelea factor P2 (4), daucosterol (5), (+)-3-hydroxy 1,5-diphenyl-l-pentanone (6), 4-ethoxy-benzoic acid (7), 2,4,6-Trimethoxy-benzoic acid (8),(+)-afzelechin (9), fumaric acid (10), N,N-dimethyl-L-aspartic acid (11), umbelliferone (12),daphniretin (13) and a novel bicoumarin named bicoumastechamin (1). Among the known compounds, 7, 8, 9, 10 and 11 were first isolated from this plant, and 6 was first isolated from the natural resources. Their structures have been elucidated on the basis of spectral data. In vitro bioassays showed that 4 inhibited cancer cell growth, 13 exhibited immunomodulatory activity, and 6 exhibited both immunomodulatory and anti-tumor activity.