ANNONACEOUS ACETOGENINS OF THE SEEDS FROM ANNONA MURICATA

• 来源期刊: 亚洲天然物产研究（英文版）
• 学科: 生物学
• 关键词: Annona muricata Annonaceae Acetogenins Muricatenol 2,4-cis-gigantetrocinone 2,4-trans-gigantetrocinone 2,4-trans-isoannonacin- l 0-one 2,4-trans-isoannonacin Anfitumor activities
• 年，卷（期）: 2001,（4）
• 页码范围: 267-276
• 页数: 10页
• 分类号: Q94
• 语种: 英文

摘要

Muricatenol (1) is a new C37 non-THF ring acetogenin with four hydroxyls and one isolated double bond in the long aliphatic chain. 2,4-cis-Gigantetrocinone (2) and 2,4-trans gigantetrocinone (3) have been isolated as their acetates by preparative TLC. 2,4-trans Isoannonacin-10-one (4) and 2,4-trans-isoannonacin (5) have been isolated as only 2,4-trans-form for the first time (no cis-form). Also four known acetogenins, gigantetrocin-A (6), gigantetrocin-B (7), annomontacin (8), gigantetronenin (9) and a mixture of N-fatty acyl tryptamines have been isolated (10). Their structures have been established on the basis of spectral analyses. The CHC13 fraction of the seeds showed strong antitumor activities.