Two new sesquiterpenoids, 4,5-epoxy-13-methoxy-l(10)-germacren-12,6-olide and 4,5-epoxy 13-acetoxy-l(10)-germacren-12,6-olide, were isolated from the leaves of Magnolia grandiflora together with six known compounds, 2α-hydroxy-dihydroparthenolide, parthenolide, cos tunolide, syringaresinol, (+) medioresinol and 6,7-dimethoxycoumarin. The structures of the new compounds were elucidated on the basis of spectroscopic methods and X-ray diffraction.