THE EFFECT OF INTERLEUKIN-6 ON THE PROLIFERATION OF PROSTATE CANCER CELLS IN VITRO AND THE MODULATION OF THIS PROCEDURE

• 来源期刊: 同济医科大学学报(外文版)
• 学科: 医学
• 关键词: 亚军
• 年，卷（期）: 2001,（3）
• 页码范围: 225-227
• 页数: 3页
• 分类号: R737.25
• 语种: 中文

摘要

The role of interleukin-6 (IL-6) in the growth of an androgen-independent prostate cancer cell line (PC-3m) was defined and the effect of dexamethasone, which was previously shown to modulate IL-6/IL-6 receptor (IL-6R) on this procedure was investigated. By using a pretty sensitive and specific enzyme immunoassay (ELISA), it was found that PC-3m produced certain IL-6, but there was no difference in IL-6 secretion between the group with or without dexamethasone treatment. It was also found that PC-3m cells could not be stimulated to grow by exogenous IL-6 (P>0.05), while it could be inhibited to grow by anti-IL-6 monoclonal antibody and dexamethasone with a dose-dependent fashion. Our observation indicated that IL-6 acted as an autocrine growth factor for PC-3m, and dexamethasone could inhibit cell proliferation by a mechanism independent of its effect on IL-6 mRNA expression.