磷化铝中毒抑制大鼠胆碱酯酶及阿托品和氯解磷啶的作用

• 作者: Sharda Shah PESHIN Shivani MHrRA Shyam Bala LALL
• 来源期刊: 中国药理学报（英文版）
• 学科: 医学
• 关键词: 中毒 磷化铝 胆碱酯酶类 血压 阿托品 氯解磷啶
• 年，卷（期）: 2001,（1）
• 所属期刊栏目: 研究原著
• 页码范围: 37-39
• 页数: 3页
• 分类号: R96
• 语种: 英文

摘要

AIM: To investigate the cholinesterase inhibition and effect of atropine and pralidoxime (PAM) treatment on the survival time in the rat model of aluminium phosphide (ALP) poisoning. METHODS: The rats were treated with AlP (10 mg/kg; 5.55×LD50; ig) and the survival time was noted. The effect of atropine (1 mg/kg, ip) and PAM (5 mg/kg, ip) was noted on the above. Atropine and PAM were administered 5 min after AlP. Plasma cholinesterase levels were measured spectrophotometrically in the control and AlP treated rats 30 min after administration. RESULTS: Treaanent with atropine and PAM increased the survival time by 2.5 fold (1.4 h ±0.3 h vs 3.4 h±2.5 h, P＜0.01) in9 out of 15 animals and resulted in total survival of the 6 remaining animals. Plasma cholinesterase levels were inhibited by 47％, (438±74) U/L in AlP treated rats as compared tocontrol (840±90) U/L (P＜0.01). CONCLUSION: This preliminary study concludes that AlP poisoning causes cholinesterase inhibition and responds to treatment with atropine and PAM.