STUDY ON B7-1 PROTEIN'S EXPRESSION IN BIOPSIES IN RENAL TRANSPLANTATION

• 作者: 刘雅峰 杜斌 田普训 薛武军
• 来源期刊: 西安交通大学学报：英文版
• 学科: 医学
• 关键词: RENAL TRANSPLANTATION REJECTION costimulatory moleales
• 年，卷（期）: 2002,（2）
• 页码范围: 166-169
• 页数: 4页
• 分类号: R692.5

摘要

Objective To study the expression of B7-1 protein in biopsies in allograft renal transplantation,and explore the expression patern and the functional role of B7-1 molecule. Methods Renal allograft sample tissue by Tru-cut needle aspiration were taken from 64 paients(42 male,22 female) with renal transplantation, aging from 17 to 58 years old; 64 cases were categorized into six groups: ①acute rejection (AR n=22);②accelerated rejection (AAR n=8);③chronic rejection (CR n=10 );④hyperacute rejection (HR n=4);⑤allograft with stable function (ASF n=10); ⑥health donor kidney (HDK n=10);Immunohistochemical assays(ABC) were used, and comparison B7-1 and HLA-DR expression between tubularand interstitial,the number of interstitial infiltrating lymphocytes. Results ①The sequence of the expression of B7-1 molecule in terms of intensity from the strongest to the weakest in different groups is AR group, AAR group, CR group, HR group,ASF group and HDK group; ②During acute rejection response, a large number of CD4 and CD8 T lymphocytes infiltrate kidney interstitium, accompanied by strong expression of HLA-DR in tubular cell(donor MHC-Ⅱantigen),which is the first signal necessary for T lymphocyte activation. Conclusion The results demonstrate that B7-1 expression of tubular cells as APC actively take part in immunological reactions and play an important role in expanding the immunological reactions.