The Clinical Study of Telomerase Activity in Gastric Tumor

• 来源期刊: 美国中华健康卫生杂志
• 学科: 医学
• 关键词: Stomach neoplasms Telomerase activity
• 年，卷（期）: 2002,（11）
• 页码范围: 47-49
• 页数: 3页
• 分类号: R73
• 语种: 中文

摘要

Telomerase activity was detected with both telomeric repeat amplification protocol (TRAP) - silver stain and polymerase chain reaction (PCR) - enzyme linked immuno - sorbent assay (ELISA). We have studied the telomerase activity in the 68 gastric tumors and their neighboring tissues,25 gastric ulcer, and 3 tumor cell colonies. The positive rate of telomerase activity in gastric tumors was 86.8% (59/68) and which was obviously higher than 7.3% (5/68) in the normal tissues adjacent to the tumors and 4% (1/25) in gastric ulcer. The telomerase activity was 100% (3/3) in the tumor colonies. It allowed to be seen that higher telomerase activity was associated with the origin and development of the gastric tumor. We believe that telomerase activity may be a useful clinical diagnostic marker for the gastric tumor.