p38 MAPK mediates cardiovascular and behavioral responses induced by central IL-1β and footshock in conscious rats

• 来源期刊: 中国药理学报（英文版）
• 学科: 医学
• 关键词: mitogen-activated protein kinase p38 interleukin-1 blood pressure motor activity
• 年，卷（期）: 2004,（3）
• 页码范围: 266-270
• 页数: 5页
• 分类号: R96
• 语种: 英文

摘要

AIM: To investigate the roles of p38 mitogen-activated protein kinase (p38 MAPK) in the cardiovascular and behavioral responses induced by intracerebral ventricular injection (icv) of interleukin- 1 β (IL- 1 β) or footshock.METHODS: We examined the effects of p38 MAPK on mean artery blood pressure (mABP), heart rate (HR), and motor activity (MA) during central administration of IL- 1 β, or footshock after icv SB203580 (a specific inhibitor of the p38 MAPK) with Cardiovascular and Behavior Telemetry System in conscious SD rats. RESULTS: (1) IL-1 β (icy) or footshock remarkably rise the mABP, and the maximal changes are (7.8± 1.8) and (12.3±3.5) mmHg,respectively, which was abrogated by the pretreatment with p38 inhibitor SB203580 intracerebroventricularly. (2)Compared with icv saline group, the motor activity was significantly decreased in SB203580 group with maximal changes (-7.6± 1.1) counts/min after footshock. CONCLUSION: p38 MAPK plays an important role in the pressor response induced by central administration of IL- 1 β or footshock and change of motor activity after footshock in conscious rats.