Analysis on Homocysteine's Risk to Atherosclerosis and Its Correlations with Serum Lipids

• 来源期刊: 岭南心血管病杂志(英文版)
• 关键词: Homocysteine Atherosclerosis High-performance liquid chromatography (HPLC) Two-dimensional echocardiography
• 年，卷（期）: 2004,（1）
• 页码范围: 13-16
• 页数: 4页
• 语种: 英文

摘要

Objectives To explore the homocysteine's risk to atherosclerosis and its correlations with serum lipids TG,TG and HDL-C. Methods With a cross sectional study, 490 subjects (aged 41-86 yrs, male 420 and female 70) were surveyed in 1999 in Guangdong Province, China. The main research variables were homocysteine (Hcy) and the serum lipids total cholesterol (TC), triglyceride (TG),high-density lipoprotein cholesterol(HDL-C). Results Hcy was a possible risk factor resulting in atherosclerosis (OR=l.15, 0.05 ＜P ＜0.10, n=108) with Logistic regression analysis. There is no correlation or much lower degree correlation between Hey and the serum lipids group of TC, TG, HDL-C. The canonical correlation coefficient between V1 and W1 was R1,Can =0.12(0.05＜P＜0.10, n=490, V1=Hcy, W1= - 0.9446 * TC + 0.1588 * TG + 0.6009 * HDL-C). Conclusions It is possible that Hcy is a risk factor to atherosclerosis and is independent of serum lipids group or has much lower correlation with it. It is necessary to do more research to explore the risk degree of Hcy inducing atherosclerosis and whether are there are bigger correlations or higher independence between Hcy and other risk factors during the progress of atherosclerosis.