Synthesis of (2R,3aR,8aR)-6-Chloro-3a-hydroxy-1,2,3,3a,8,8a- hexahydropyrrolo[2,3-b]indole-2-carboxylic Acid Methyl Ester by Reductive Cyclization

• 来源期刊: 中国化学（英文版）
• 学科: 化学
• 年，卷（期）: 2004,（4）
• 页码范围: 365-370
• 页数: 6页
• 分类号: O6
• 语种: 英文

摘要

A synthesis of(2R,3aR,8aR)-6-chloro-3a-hydroxy-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid methyl ester(1)was achieved.An aldol reaction with Garner aldehyde,a hydroxyl introduction by Davis reagent,and a reductive intramolecular ring-closure reaction were served as the key steps.This piece of work provides a new way to synthesize the analogues of hexahydropyrrolo[2,3-b]indole,starting from readily available chemical substrates and inexpensive reagents.