Disruption of estrogen receptor beta in mice brain results in pathological alterations resembling Alzheimer disease

• 来源期刊: 中国药理学报（英文版）
• 学科: 医学
• 关键词: beta-amyloid peptide apolipoprotein E estrogen receptor beta Alzheimer disease
• 年，卷（期）: 2004,（4）
• 页码范围: 452-457
• 页数: 6页
• 分类号: R9
• 语种: 英文

摘要

AIM: To study the pathological characteristics of the mice with estrogen receptor β (ERβ) disruption in brain.METHODS: Immunohistochemistry method was applied in the study. RESULTS: β-Amyloid peptide(Aβ42) and apolipoprotein E (ApoE) immunoreactive substances were accumulated notably in cortex and limbic structures such as the hippocampus and amygdala in brain, resembling the pathological changes of human Alzheimer disease (AD). Aβ formed cloudy-like deposits in parenchyma of brain, while apoE also deposited along or surrounding the blood vessels. CONCLUSIONS: ERβ is crucial to the development of neural degenerative disease, so modulation of Aβ metabolism via ERβ signal pathway might be beneficial for AD prevention or therapy.