Brain IL-1β was involved in reserpine-induced behavioral depression in rats

• 来源期刊: 中国药理学报（英文版）
• 学科: 医学
• 关键词: reserpine depression interleukin-1
• 年，卷（期）: 2004,（3）
• 页码范围: 293-296
• 页数: 4页
• 分类号: R96
• 语种: 英文

摘要

AIM: To investigate the mechanism of brain interleukin-1 β (IL-1 β) in reserpine-induced behavioral depression in rats. METHODS: Porsult swim test was used in the measurement of depressive behavior and ELISA was used in measurement of brain IL-1 β. RESULTS: Intraperitoneal injection of reserpine (0, 4, 6, and 8 mg/kg, ip) increased floating time in the Porsult swim test in a dose-and time-dependent manner in rats. Intracerebroventricular injection (icv) of IL-1 β receptor antagonist (IL-lra, 6 mg/kg) blocked the increment of floating time in Porsult swim test at 48 and 72 h after reserpine injection, but not at 1 and 24 h after injection. Brain IL-lβ increased after reserpine treatment in posterior cortex, hippocampus, and hypothalamus. The increase of IL-1 β concentration starts at 24 hours after injection of reserpine and reached the peak at 48 h. CONCLUSION: Reserpine induced behavioral depression partially via brain interleukin-1 β generation.