Tannin inhibits HIV-1 entry by targeting gp41

• 来源期刊: 中国药理学报（英文版）
• 学科: 医学
• 关键词: tannin drug dose-response relationship enzyme-linked immunosorbent assay HIV envelope prorein gp41 phenols plant extracts medical plants
• 年，卷（期）: 2004,（2）
• 页码范围: 213-218
• 页数: 6页
• 分类号: R96
• 语种: 英文

摘要

AIM: To investigate the mechanism by which tannin inhibits HIV-1 entry into target cells. METHODS: The inhibitory activity of tannin on HIV-1 replication and entry was detected by p24 production and HIV-1-mediated cell fusion, respectively. The inhibitory activity on the gp41 six-helix bundle formation was determined by an improved sandwich ELISA. RESULTS: Tannins from different sources showed potent inhibitory activity on HIV-1 replication,HIV-1-mediated cell fusion, and the gp4 six-helix bundle formation. CONCLUSION: Tannin inhibits HIV-1 entry into target cells by interfering with the gp41 six-helix bundle formation, thus blocking HIV-1 fusion with the target cell.