EFFECTS OF EXPERIMENTAL VARICOCELE ON MITOCHONDRIA CALCIUM AND CYTOCHROME C OF EPIDIDYMIS IN ADOLESCENT RATS

• 来源期刊: 亚洲男性学杂志(英文版)
• 学科: 医学
• 年，卷（期）: 2004,（3）
• 页码范围: 248
• 页数: 1页
• 分类号: R697.2
• 语种: 中文

摘要

Aim: To investigate the effect of experimental varicocele on mitochondrial calcium and cytochrome C of the epididymal cells in adolescent rats. Methods: Forty male adult Wistar rats were divided into two groups randomly: the varicocele group (VG) and the sham operated group (SOG). Varicocele was produced by partial ligation of the left renal vein. Bilateral epididymides were removed after ten weeks. The mitochondrial calcium and cytochrome C levels of the epididymal cells were determined. Results: The mi-tochondrial calcium was decreased (P<0.01) while the cytochrome C increased (P<0.05) markedly in the experimental group compared with the controls. Conclusion: Varicocele-induced calcium dyshomeostasis and mitochondrial damage of the epididymal cells may play an important role in causing subfertility.