The experimental study of cross-talk behavior is presented for mixed-mode integrated circuits based on SOI (Silicon-on-insulator) structure. Different strategies to reduce cross-talk are investigated. The influence of bulk contact, separation distance, the guard ring isolation and mesa isolation on the cross-talk has been compared. At the same time, the effect of load impedance on the cross-talk is also included. The results can serve as a guideline for designing low-noise coupling SOI mixed-mode IC''''s.