A Valuable Synthetic Route to the Enantiopure Functionalized N-Substituted Aziridines

• 来源期刊: 中国化学（英文版）
• 学科: 化学
• 年，卷（期）: 2004,（4）
• 页码范围: 384-389
• 页数: 6页
• 分类号: O6
• 语种: 英文

摘要

Chiral butyrolacto[3,4-b]-2(S)-6(R)-1-N-akylaziridines 7 were synthesized in enantiopure form utilizing racemic 5-methoxy-3-bromo-2(5H)-furanone(5)and available amines(6)as key precursors.After highly effective reduction of 7,the functionalized 2(S),3(R)-dihyroxymethyl-N-alkylaziridines(8)were obtained in good yields with ≥98% ee.This is a simple and pratical method for the preparation of enantiopure aziridines which are important intermediates in the synthesis of biologic active molecules.