Diastereoselective Synthesis of Chiral Pyrrolidine and Piperidine Ring Systems

• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2004,（7）
• 页码范围: 727-731
• 页数: 5页
• 语种: 英文

摘要

A diastereoselective method for the synthesis of chiral pyrrolidine and piperidine ring containing compounds was described. The protocol of bromination followed by aminocyclization furnishes an easily handled while highly efficient procedure for the intramolecular amidation of an isolated double bond. High diastereomeric excess was observed in this synthetic procedure.